SCHEMBL7214447

SCHEMBL7214447

COc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)Nc2ccc(Br)cc2)cc1OC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 1/20 0.65
SLC10A1 Q14973 1/20 0.65
SLC10A6 Q3KNW5 1/20 0.65
GPR27 Q9NS67 1/20 0.60
KMT2A Q03164 3/20 0.58
MEN1 O00255 2/20 0.58
SMN1; SMN2 Q16637 5/20 0.56
ALDH1A1 P00352 4/20 0.56
MAPT P10636 4/20 0.56
GFER P55789 1/20 0.56
HSD17B10 Q99714 1/20 0.56
POLB P06746 2/20 0.54
LMNA P02545 5/20 0.53
HTT P42858 2/20 0.53
MAPK1 P28482 4/20 0.52
KEAP1 Q14145 1/20 0.52
NFE2L2 Q16236 1/20 0.52
ALOX15 P16050 1/20 0.52
HPGD P15428 2/20 0.50
GAA P10253 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7128123 0.87 SLC10A6 (0.71) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7116008 0.86 SLC10A6 (0.85) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7212991 0.81 SLC10A6 (0.73) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7126120 0.81 SLC10A6 (0.98) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7208184 0.81 SLC10A6 (0.76) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7213211 0.80 GPR27 (0.67) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7120319 0.80 SLC10A6 (0.76) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7626967 0.80 SLC10A6 (0.68) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL7213164 0.80 SLC10A6 (0.71) SLC10A2SLC10A1SLC10A6GPR27KMT2A
SCHEMBL5598202 0.80 ALDH1A1 (0.55) SLC10A2SLC10A1SLC10A6GPR27KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US claimed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN claimed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP claimed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO claimed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US disclosed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN disclosed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO disclosed