Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744412 | 0.85 | NPC1 (0.47) | NPC1MAPTALDH1A1LMNACRHBP | |
| SCHEMBL29177211 | 0.83 | NPC1 (0.43) | NPC1MAPTALDH1A1LMNACRHBP | |
| SCHEMBL20718858 | 0.80 | NPC1 (0.42) | NPC1MAPTALDH1A1LMNACRHBP | |
| SCHEMBL31509441 | 0.78 | NPC1 (0.44) | NPC1MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL26984384 | 0.76 | ALDH1A1 (0.45) | NPC1ALDH1A1LMNAKMT2AHTT | |
| SCHEMBL31572395 | 0.75 | PDE1C (0.43) | NPC1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL1641895 | 0.73 | MAPT (0.47) | NPC1MAPTALDH1A1LMNACRHBP | |
| SCHEMBL10531013 | 0.73 | LMNA (0.54) | NPC1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL16207392 | 0.73 | GAA (0.40) | ALDH1A1LMNAL3MBTL1KMT2AHTT | |
| SCHEMBL20298767 | 0.72 | NPC1 (0.52) | NPC1MAPTALDH1A1LMNAAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |