Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124645 | 0.82 | GRM5 (0.54) | OGG1GRM5KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL99367 | 0.81 | GRM5 (0.35) | OGG1GRM5MAPT | |
| SCHEMBL10316839 | 0.81 | OGG1 (0.53) | OGG1GRM5KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL105734 | 0.79 | OGG1 (0.57) | OGG1GRM5KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL96594 | 0.79 | HPGD (0.49) | KMT2AL3MBTL1MEN1SLC6A4HPGD | |
| SCHEMBL10451483 | 0.77 | OGG1 (0.56) | OGG1GRM5KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL97275 | 0.77 | POLB (0.43) | KMT2AL3MBTL1ALDH1A1MEN1KDM4E | |
| Chloromethane SCHEMBL27541396 | 0.77 | OGG1 (0.56) | OGG1GRM5KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9353539 | 0.77 | MTNR1A (0.42) | KMT2AALDH1A1MEN1KDM4EHPGD | |
| SCHEMBL43675 | 0.77 | MTNR1A (0.42) | KMT2AALDH1A1MEN1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617426-B1 | Peptide analogs of given formula; useful in treating neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury | MERCK SHARP & DOHME CORP. | 2003-09-09 | — | — | US | claimed |