Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9353539 | 1.00 | MTNR1A (0.42) | MTNR1AMTNR1BGAACYP1A2CYP2C9 | |
| SCHEMBL5803766 | 0.80 | TAS1R3 (0.48) | MTNR1AMTNR1BGAAPKMKDM4E | |
| SCHEMBL8733198 | 0.79 | POLB (0.41) | MTNR1AMTNR1BGAACYP1A2CYP2C9 | |
| SCHEMBL8889549 | 0.78 | RAB9A (0.40) | KDM4EKMT2AMEN1HPGD | |
| SCHEMBL11328816 | 0.78 | LDHA (0.47) | GAAKDM4EKMT2ALMNAMEN1 | |
| SCHEMBL11685356 | 0.78 | TDP1 (0.43) | KMT2AALDH1A1HPGDMAOAMAOB | |
| SCHEMBL446679 | 0.78 | MTNR1A (0.40) | MTNR1AMTNR1BGAACYP1A2CYP2C9 | |
| SCHEMBL97275 | 0.78 | POLB (0.43) | GAACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL9415979 | 0.78 | ESR2 (0.41) | GAACYP1A2CYP2C9PKMCYP2C19 | |
| SCHEMBL7419291 | 0.78 | CYP1A2 (0.48) | CYP1A2KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1406 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114933620-A | Azithromycin derivatives having epithelial barrier enhancing properties | 艾比恩多制药有限责任公司 | 2022-08-23 | — | — | CN | claimed |
| US-20220106349-A1 | Compounds | EPIENDO PHARMACEUTICALS EHF (IS) | 2022-04-07 | — | — | US | claimed |
| US-11236120-B2 | Azithromycin derivatives with epithelial barrier enhancement properties | EPIENDO PHARMACEUTICALS EHF (IS) | 2022-02-01 | — | — | US | claimed |
| US-20200317710-A1 | Azithromycin Derivatives With Epithelial Barrier Enhancement Properties | EPIENDO PHARMACEUTICALS EHF (IS) | 2020-10-08 | — | — | US | claimed |
| EP-3708573-A1 | AZITHROMYCIN DERIVATIVES WITH EPITHELIAL BARRIER ENHANCEMENT PROPERTIES | EpiEndo Pharmaceuticals ehf. (IS) | 2020-09-16 | — | — | EP | claimed |
| US-10723752-B2 | Azithromycin derivatives with epithelial barrier enhancement properties | EPIENDO PHARMACEUTICALS EHF (IS) | 2020-07-28 | — | — | US | claimed |
| EP-3377511-B1 | AZITHROMYCIN DERIVATIVES WITH EPITHELIAL BARRIER ENHANCEMENT PROPERTIES | EPIENDO PHARMACEUTICALS EHF (IS) | 2020-05-13 | — | — | EP | claimed |
| US-20180354981-A1 | Azithromycin Derivatives With Epithelial Barrier Enhancement Properties | EPI-ENDO PHARMACEUTICALS EHF (IS) | 2018-12-13 | — | — | US | claimed |
| EP-3377511-A1 | AZITHROMYCIN DERIVATIVES WITH EPITHELIAL BARRIER ENHANCEMENT PROPERTIES | Epi-endo Pharmaceuticals Ehf. (IS) | 2018-09-26 | — | — | EP | claimed |
| EP-1512397-B1 | O-SUBSTITUTED HYDROXYARYL DERIVATIVES | INST MED MOLECULAR DESIGN INC (JP) | 2014-10-08 | — | — | EP | claimed |
| US-4438136-A | INHIBITION OF THROMBOXANE ACTIVITY | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-03-20 | — | — | US | claimed |
| EP-0094498-A2 | Antiatherosclerotic 1-piperazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1983-11-23 | — | — | EP | claimed |
| EP-0013608-B1 | SUBSTITUTED BICYCLO (2,2,1)HEPTANES AND HEPT-2-ENES AND THEIR PHARMACEUTICAL COMPOSITIONS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1983-06-15 | — | — | EP | claimed |
| US-4269773-A | CEPHALOSPORINS | SHIONOGI & CO., LTD. (JP) | 1981-05-26 | — | — | US | claimed |
| US-4267340-A | BACTERICIDES; SYNTHESIS OF PENICILLINS AND CEPHALOSPORINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-05-12 | — | — | US | claimed |
| EP-0003584-B1 | PHENOXYPROPANOIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AG (DE) | 1981-01-21 | — | — | EP | claimed |
| US-4070458-A | MICRBIAL ENZYME | SANRAKU-OCEAN CO., LTD. (JA) | 1978-01-24 | — | — | US | claimed |
| US-4055468-A | TETRAPEPTIDE | SANRAKU-OCEAN CO., LTD. (JA) | 1977-10-25 | — | — | US | claimed |
| US-4009159-A | PENICILLINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1977-02-22 | — | — | US | claimed |
| US-3993646-A | Process for the ring expansion of penicillins to cephalosporin compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1976-11-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106349-A1 | Compounds | CFTR, AQP1, CTSA | MTNR1A 1638/4885MTNR1B 1343/4885GAA 130/4885 |
| US-11236120-B2 | Azithromycin derivatives with epithelial barrier enhancement properties | CFTR, AQP1, CTSA | MTNR1A 1652/4885MTNR1B 1655/4885GAA 315/4885 |
| US-20180354981-A1 | Azithromycin Derivatives With Epithelial Barrier Enhancement Properties | CFTR, AQP1, CTSA | MTNR1A 1652/4885MTNR1B 1655/4885GAA 315/4885 |
| US-20200317710-A1 | Azithromycin Derivatives With Epithelial Barrier Enhancement Properties | CFTR, AQP1, CTSA | MTNR1A 1652/4885MTNR1B 1655/4885GAA 315/4885 |
| US-10723752-B2 | Azithromycin derivatives with epithelial barrier enhancement properties | CFTR, AQP1, CTSA | MTNR1A 1652/4885MTNR1B 1655/4885GAA 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.