Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 3/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542238 | 0.86 | SCN1A (0.51) | HTR1AOPRK1LMNACHRM2CYP3A4 | |
| SCHEMBL1002853 | 0.84 | MAPT (0.53) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| Benzene SCHEMBL28299279 | 0.82 | KMT2A (0.51) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL15954597 | 0.82 | MAPT (0.51) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| Bromide SCHEMBL4760758 | 0.82 | MAPT (0.51) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| SCHEMBL1004433 | 0.82 | CYP3A4 (0.55) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| SCHEMBL1003944 | 0.81 | LMNA (0.58) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| SCHEMBL421013 | 0.81 | LMNA (0.58) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| SCHEMBL1004461 | 0.81 | LMNA (0.58) | OPRK1LMNACHRM2CYP3A4SLC6A3 | |
| SCHEMBL5566506 | 0.81 | LMNA (0.58) | OPRK1LMNACHRM2CYP3A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1620421-A | Substituted alkyl diammine compound | EKOT RHEIN MEDICINE CO LTD (CH) | 2005-05-25 | — | — | CN | disclosed |
| EP-1335899-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | Actelion Pharmaceuticals Ltd. (CH) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002038534-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-05-16 | — | — | WO | disclosed |