Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216754 | 0.89 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7216255 | 0.86 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7216641 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL7212043 | 0.82 | PTGS2 (0.73) | PTGS2PTGS1CA1CA2 | |
| SCHEMBL7210640 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL5314069 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL5311859 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8504218 | 0.80 | PTGS2 (0.38) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL7210319 | 0.79 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7215260 | 0.78 | PTGS2 (0.57) | PTGS2PTGS1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | disclosed |