Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL720788 | 1.00 | TRPA1 (0.53) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL157373 | 0.95 | TRPA1 (0.49) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL23200506 | 0.95 | TRPA1 (0.49) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoyl Formic Acid SCHEMBL16047491 | 0.93 | TRPA1 (0.46) | TRPA1DAOTSHRNAPRTRXRA | |
| Isophthalic Acid SCHEMBL10943672 | 0.90 | TRPA1 (0.46) | TRPA1RXRARXRBNR4A1NR4A2 | |
| Benzoic Acid SCHEMBL272637 | 0.90 | TRPA1 (0.44) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL16045755 | 0.89 | TRPA1 (0.43) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL16044771 | 0.89 | TRPA1 (0.43) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL7624769 | 0.88 | TRPA1 (0.42) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL7630225 | 0.88 | TRPA1 (0.42) | TRPA1DAOTSHRNAPRTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107263945-B | Polymer interlayers including two kinds or the blend of more kinds of resins | 首诺公司 | 2019-08-20 | — | — | CN | claimed |
| CN-107263945-A | Polymer interlayers including two kinds or the blend of more kinds of resins | 首诺公司 | 2017-10-20 | — | — | CN | claimed |
| EP-2337872-B1 | METAL EXTRACTANT REAGENTS HAVING INCREASED RESISTANCE TO DEGRADATION | CYTEC TECH CORP (US) | 2016-11-16 | — | — | EP | claimed |
| US-8609063-B2 | Metal extractant reagents having increased resistance to degradation | CYTEC TECHNOLOGY CORP. (US) | 2013-12-17 | — | — | US | claimed |
| US-20130069008-A1 | METAL EXTRACTANT REAGENTS HAVING INCREASED RESISTANCE TO DEGRADATION | CYTEC TECHNOLOGY CORP. (US) | 2013-03-21 | — | — | US | claimed |
| US-8349208-B2 | Modification of copper/iron selectivity in copper solvent extraction systems | CYTEC TECHNOLOGY CORP. (US) | 2013-01-08 | — | — | US | claimed |
| US-8329124-B2 | Metal extractant reagents having increased resistance to degradation | CYTEC TECHNOLOGY CORP. (US) | 2012-12-11 | — | — | US | claimed |
| US-20120282156-A1 | MODIFICATION OF COPPER/IRON SELECTIVITY IN COPPER SOLVENT EXTRACTION SYSTEMS | CYTEC TECHNOLOGY CORP. (US) | 2012-11-08 | — | — | US | claimed |
| US-8282857-B2 | Modification of copper/iron selectivity in copper solvent extraction systems | CYTEC TECHNOLOGY CORP. (US) | 2012-10-09 | — | — | US | claimed |
| US-20120052428-A1 | PENTANEDIOL ESTER CONTAINING PHOTOCONDUCTORS | XEROX CORPORATION (US) | 2012-03-01 | — | — | US | claimed |
| EP-1613784-A1 | COMPOSITION AND PROCESS FOR THE SOLVENT EXTRACTION OF METALS USING ALDOXIME OR KETOXIME EXTRACTANTS | CYTEC TECHNOLOGY CORP. (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004094676-A1 | COMPOSITION AND PROCESS FOR THE SOLVENT EXTRACTION OF METALS USING ALDOXIME OR KETOXIME EXTRACTANTS | CYTEC TECHNOLOGY CORP. (US) | 2004-11-04 | — | — | WO | claimed |
| US-20040208807-A1 | Composition and process | CYTEC TECHNOLOGY CORP. | 2004-10-21 | — | — | US | claimed |
| US-6726887-B1 | SOLVENT EXTRACTION COMPOSITION COMPRISING ONE OR MORE ORTHOHYDROXYARYLALDOXIMES OR ORTHOHYDROXYARYLKETOXIMES AND ONE OR MORE ESTERS SUBSTITUTED WITH HYDROXY GROUP; EXTRACTION OF METALS FROM AQUEOUS SOLUTIONS OBTAINED BY LEACHING ORES | CYTEC TECHNOLOGY CORP. | 2004-04-27 | — | — | US | claimed |
| EP-1141424-B1 | COMPOSITION OF OXIME AND HYDROXY-ESTER FOR THE SOLVENT EXTRACTION OF METALS | AVECIA LTD (GB) | 2003-07-30 | — | — | EP | claimed |
| EP-1141424-A1 | COMPOSITION OF OXIME AND HYDROXY-ESTER FOR THE SOLVENT EXTRACTION OF METALS | Avecia Limited (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000036167-A1 | COMPOSITION OF OXIME AND HYDROXY-ESTER FOR THE SOLVENT EXTRACTION OF METALS | AVECIA LIMITED (GB) | 2000-06-22 | — | — | WO | claimed |
| EP-0416822-B1 | Stain-resistant plasticizer compositions and method of making same | VELSICOL CHEMICAL CORP (US) | 1996-03-13 | — | — | EP | claimed |
| US-5039728-A | Floor and wall coverings; vinly chloride homo- and copolymers | HULS AMERICA INC. (US) | 1991-08-13 | — | — | US | claimed |
| EP-0416822-A2 | Stain-resistant plasticizer compositions and method of making same | VELSICOL CHEMICAL CORPORATION (US) | 1991-03-13 | — | — | EP | claimed |