Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL23200506 | 1.00 | TRPA1 (0.49) | TRPA1TSHRDAONAPRTRXRA | |
| Benzoic Acid SCHEMBL720788 | 0.95 | TRPA1 (0.53) | TRPA1TSHRDAONAPRTRXRA | |
| Benzoic Acid SCHEMBL721538 | 0.95 | TRPA1 (0.53) | TRPA1TSHRDAONAPRTRXRA | |
| Benzoyl Formic Acid SCHEMBL16047491 | 0.88 | TRPA1 (0.46) | TRPA1TSHRDAONAPRTRXRA | |
| Benzene SCHEMBL28271106 | 0.87 | TRPA1 (0.47) | TRPA1VNN1SLC6A2SLC6A4SLC6A3 | |
| Isophthalic Acid SCHEMBL10943672 | 0.86 | TRPA1 (0.46) | TRPA1RXRARXRBNR4A1NR4A2 | |
| Benzoic Acid SCHEMBL272637 | 0.86 | TRPA1 (0.44) | TRPA1TSHRDAONAPRTRXRA | |
| Benzoic Acid SCHEMBL16044771 | 0.85 | TRPA1 (0.43) | TRPA1TSHRDAONAPRTRXRA | |
| Benzoic Acid SCHEMBL16045755 | 0.85 | TRPA1 (0.43) | TRPA1TSHRDAONAPRTRXRA | |
| Benzoic Acid SCHEMBL7624769 | 0.84 | TRPA1 (0.42) | TRPA1TSHRDAONAPRTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 535 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109795-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | EASTMAN CHEMICAL COMPANY (US) | 2026-04-23 | — | — | US | claimed |
| EP-4598999-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | Eastman Chemical Company (US) | 2025-08-13 | — | — | EP | claimed |
| WO-2024076953-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | EASTMAN CHEMICAL COMPANY (US) | 2024-04-11 | — | — | WO | claimed |
| CN-108795547-B | Plant compound engine oil containing graphene-inorganic nonmetallic fibers | 颜凤生 | 2021-03-23 | — | — | CN | claimed |
| US-10773501-B2 | Multiple layer interlayer resisting defect formation | SOLUTIA INC. (US) | 2020-09-15 | — | — | US | claimed |
| CN-111635583-A | High-temperature-resistant environment-friendly polyethylene cable material and preparation method thereof | 中广核三角洲（太仓）检测技术有限公司 | 2020-09-08 | — | — | CN | claimed |
| CN-107236588-B | Lubricating oil | 北京广普开元润滑油有限公司 | 2020-03-10 | — | — | CN | claimed |
| CN-110699162-A | Lubricating oil for automobile detection | 秦引 | 2020-01-17 | — | — | CN | claimed |
| EP-3200994-B1 | MULTIPLE LAYER INTERLAYER RESISTING DEFECT FORMATION | SOLUTIA INC (US) | 2019-01-30 | — | — | EP | claimed |
| US-20180354245-A1 | MULTIPLE LAYER INTERLAYER RESISTING DEFECT FORMATION | SOLUTIA INC. (US) | 2018-12-13 | — | — | US | claimed |
| WO-2014200989-A2 | POLYMER INTERLAYERS HAVING IMPROVED OPTICAL PROPERTIES | SOLUTIA INC. (US) | 2014-12-18 | — | — | WO | claimed |
| US-20140363651-A1 | POLYMER INTERLAYERS HAVING IMPROVED OPTICAL PROPERTIES | SOLUTIA INC. (US) | 2014-12-11 | — | — | US | claimed |
| US-20140364550-A1 | POLYMER INTERLAYERS COMPRISING A BLEND OF TWO OR MORE RESINS | SOLUTIA INC. (US) | 2014-12-11 | — | — | US | claimed |
| US-20140364549-A1 | POLYMER INTERLAYERS HAVING IMPROVED OPTICAL PROPERTIES | SOLUTIA INC. (US) | 2014-12-11 | — | — | US | claimed |
| US-8372912-B2 | Polyvinyl chloride compositions | EASTMAN CHEMICAL COMPANY (US) | 2013-02-12 | — | — | US | claimed |
| US-5223106-A | Precuring | ASTER, INC. (US) | 1993-06-29 | — | — | US | claimed |
| US-5143650-A | ELECTROPHORETIC COATABLE SEALANT COMPOSITIONS COMPRISING POLYVINYL CHLORIDE AND FURNACE CARBON BLACK | ASTER, INC. (US) | 1992-09-01 | — | — | US | claimed |
| EP-0486307-A2 | Electrophoretic coatable sealant compositions | ASTER, Inc. (US) | 1992-05-20 | — | — | EP | claimed |
| US-4900771-A | FINELY DIVIDED POLYVINYL CHLORIDE DISPERSED IN THERMOPLASTIC PLASTICIZER; STABLE ADHESIVE AND SEALANT FOR AUTOMOBILE BODIES | ASTER, INC. (US) | 1990-02-13 | — | — | US | claimed |
| EP-0212771-A1 | Viscosity stable plastisol sealant | PROTECTIVE TREATMENTS INC. (US) | 1987-03-04 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260109795-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | TRIM4, TRIM58, TRA2B | TRPA1 1153/4885TSHR 3046/4885DAO 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.