Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL721538 | 1.00 | TRPA1 (0.53) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL157373 | 0.95 | TRPA1 (0.49) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL23200506 | 0.95 | TRPA1 (0.49) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoyl Formic Acid SCHEMBL16047491 | 0.93 | TRPA1 (0.46) | TRPA1DAOTSHRNAPRTRXRA | |
| Isophthalic Acid SCHEMBL10943672 | 0.90 | TRPA1 (0.46) | TRPA1RXRARXRBNR4A1NR4A2 | |
| Benzoic Acid SCHEMBL272637 | 0.90 | TRPA1 (0.44) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL16045755 | 0.89 | TRPA1 (0.43) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL16044771 | 0.89 | TRPA1 (0.43) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL7624769 | 0.88 | TRPA1 (0.42) | TRPA1DAOTSHRNAPRTRXRA | |
| Benzoic Acid SCHEMBL7630225 | 0.88 | TRPA1 (0.42) | TRPA1DAOTSHRNAPRTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 766 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109795-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | EASTMAN CHEMICAL COMPANY (US) | 2026-04-23 | — | — | US | claimed |
| US-12365785-B2 | Glycol ether aryl ester plasticizer | EASTMAN CHEMICAL COMPANY (US) | 2025-07-22 | — | — | US | claimed |
| WO-2024076953-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | EASTMAN CHEMICAL COMPANY (US) | 2024-04-11 | — | — | WO | claimed |
| CN-115975075-A | Catalyst component for olefin polymerization, catalyst and application | 中国石油化工股份有限公司 | 2023-04-18 | — | — | CN | claimed |
| CN-111907155-B | Intermediate film and laminated glass comprising same | 长春石油化学股份有限公司 | 2023-01-24 | — | — | CN | claimed |
| US-20220227962-A1 | GLYCOL ETHER ARYL ESTER PLASTICIZER | EASTMAN CHEMICAL COMPANY (US) | 2022-07-21 | — | — | US | claimed |
| EP-3990532-A1 | GLYCOL ETHER ARYL ESTER PLASTICIZER | Eastman Chemical Company (US) | 2022-05-04 | — | — | EP | claimed |
| US-20210028444-A1 | THIN FILM CERAMICS THAT OFFER ELECTRIC AND ELECTROCHEMICAL PROPERTIES USING NANOPOWDERS OF CONTROLLED COMPOSITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-01-28 | — | — | US | claimed |
| WO-2021010911-A1 | AN EASILY APPLICABLE HYDROPHOBIC COATING COMPOSITION TO IMPROVE MOISTURE AND WATER RESISTANCE OF THE LOCKING SYSTEMS OF THE LAMINATE FLOORING PARQUETS | AGT AĞAÇ SANAYİ VE TİCARET ANONİM ŞİRKETİ (TR) | 2021-01-21 | — | — | WO | claimed |
| WO-2020263593-A1 | GLYCOL ETHER ARYL ESTER PLASTICIZER | EASTMAN CHEMICAL COMPANY (US) | 2020-12-30 | — | — | WO | claimed |
| US-20040208807-A1 | Composition and process | CYTEC TECHNOLOGY CORP. | 2004-10-21 | — | — | US | claimed |
| US-20030147838-A1 | Cosmetic films | OPI PRODUCTS, INC. | 2003-08-07 | — | — | US | claimed |
| US-20030124154-A1 | Cosmetic films | OPI PRODUCTS, INC. | 2003-07-03 | — | — | US | claimed |
| US-RE37951-E1 | Automotive additives and sealants containing waste powder prime | HENKEL CORPORATION | 2002-12-31 | — | — | US | claimed |
| EP-0673916-B1 | Preparation of 2,2,4-trimethyl-1,3-pentanediol dibenzoate and di(alkyl-substituted) benzoates | VELSICOL CHEMICAL CORP (US) | 1998-01-07 | — | — | EP | claimed |
| EP-0416822-B1 | Stain-resistant plasticizer compositions and method of making same | VELSICOL CHEMICAL CORP (US) | 1996-03-13 | — | — | EP | claimed |
| EP-0673916-A1 | Preparation of 2,2,4-trimethyl-1,3-pentanediol dibenzoate and di(alkyl-substituted) benzoates | VELSICOL CHEMICAL CORPORATION (US) | 1995-09-27 | — | — | EP | claimed |
| US-5153342-A | Esterification of 2,2,4-trimethyl-1,3-pentanediol with (alkyl) benzoic acids using basic catalysts | HULS AMERICA INC. (US) | 1992-10-06 | — | — | US | claimed |
| US-5039728-A | Floor and wall coverings; vinly chloride homo- and copolymers | HULS AMERICA INC. (US) | 1991-08-13 | — | — | US | claimed |
| EP-0416822-A2 | Stain-resistant plasticizer compositions and method of making same | VELSICOL CHEMICAL CORPORATION (US) | 1991-03-13 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365785-B2 | Glycol ether aryl ester plasticizer | DAGLA, DDT, PPARG | TRPA1 4212/4885DAO 2632/4885TSHR 2825/4885 |
| US-20220227962-A1 | GLYCOL ETHER ARYL ESTER PLASTICIZER | DAGLA, DDT, PPARG | TRPA1 4212/4885DAO 2632/4885TSHR 2825/4885 |
| US-20260109795-A1 | HIGH REFRACTIVE INDEX POLYVINYL ACETAL RESINS MODIFIED WITH CYCLIC ALDEHYDES | TRIM4, TRIM58, TRA2B | TRPA1 1153/4885DAO 3021/4885TSHR 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.