Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | EIF4E | P06730 | 1/20 | 0.49 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217216 | 0.86 | RAB9A (0.71) | CYP19A1ABL1NPC1RAB9AKDM4E | |
| SCHEMBL7215184 | 0.85 | KDM4E (0.73) | CYP19A1ABL1NPC1RAB9AKDM4E | |
| SCHEMBL1198971 | 0.84 | ABL1 (0.51) | CYP19A1ABL1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL1505401 | 0.82 | SMN1; SMN2 (0.53) | NPC1RAB9AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7221542 | 0.82 | ALDH1A1 (0.55) | CYP19A1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7221993 | 0.81 | KDM4E (0.53) | L3MBTL1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7220984 | 0.80 | RAB9A (0.55) | NPC1RAB9AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7215145 | 0.80 | MAPT (0.61) | NPC1RAB9AKDM4ESMN1; SMN2MEN1 | |
| Bromide SCHEMBL7215296 | 0.80 | CYP19A1 (0.67) | CYP19A1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL28526442 | 0.79 | SREBF2 (0.68) | CYP19A1ABL1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| CN-1314899-A | Retinoid-associated receptor regulators | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-09-26 | — | — | CN | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |