Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 7/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.34 |
| ▸ | MMP12 | P39900 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215549 | 0.89 | DCAF1 (0.31) | ITGB3ITGA2BMMP12F2 | |
| SCHEMBL7217812 | 0.83 | CTSA (0.43) | CYP26A1CTSAMMP12MMP3MMP9 | |
| Trifluoroacetic Acid SCHEMBL7216213 | 0.83 | ITGB3 (0.34) | CYP26A1ITGB3ITGA2BMMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL7216313 | 0.81 | MCHR1 (0.35) | CYP26A1CTSAITGB3ITGA2BMMP12 | |
| SCHEMBL7379959 | 0.81 | CYP26A1 (0.42) | CYP26A1CTSAMMP12MMP3MMP9 | |
| Trifluoroacetic Acid SCHEMBL7222167 | 0.78 | MAPT (0.37) | CYP26A1CTSAITGB3ITGA2BMMP12 | |
| Trifluoroacetic Acid SCHEMBL7222355 | 0.78 | CYP26A1 (0.39) | CYP26A1CTSAITGB3ITGA2BMMP12 | |
| SCHEMBL7376518 | 0.77 | CYP26A1 (0.41) | CYP26A1CTSA | |
| SCHEMBL7381395 | 0.74 | CYP26A1 (0.45) | CYP26A1CTSAMMP12MMP3MMP9 | |
| SCHEMBL7216223 | 0.74 | MCL1 (0.32) | HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | claimed |
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | disclosed |
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |