Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCAF1 | Q9Y4B6 | 2/20 | 0.31 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7215541 | 0.89 | CYP26A1 (0.36) | F2ITGB3ITGA2BMMP12 | |
| SCHEMBL7216223 | 0.84 | MCL1 (0.32) | — | |
| SCHEMBL7216322 | 0.82 | KCNK3 (0.32) | TACR3F2F10ITGB3ITGA2B | |
| SCHEMBL7222172 | 0.79 | MAPT (0.36) | TACR3F2F10ITGB3ITGA2B | |
| SCHEMBL7222362 | 0.76 | TACR3 (0.32) | TACR3 | |
| SCHEMBL7217812 | 0.76 | CTSA (0.43) | DCAF1MMP12 | |
| Trifluoroacetic Acid SCHEMBL7216213 | 0.73 | ITGB3 (0.34) | ITGB3ITGA2BMMP12 | |
| SCHEMBL7379959 | 0.73 | CYP26A1 (0.42) | MMP12 | |
| SCHEMBL7376518 | 0.71 | CYP26A1 (0.41) | — | |
| Trifluoroacetic Acid SCHEMBL7216313 | 0.71 | MCHR1 (0.35) | F2ITGB3ITGA2BMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | claimed |
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | disclosed |
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |