Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 8/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.40 |
| ▸ | MMP12 | P39900 | 4/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379959 | 0.90 | CYP26A1 (0.42) | CTSACYP26A1MMP12MMP3MMP9 | |
| SCHEMBL7376518 | 0.83 | CYP26A1 (0.41) | CTSACYP26A1 | |
| Trifluoroacetic Acid SCHEMBL7215541 | 0.83 | CYP26A1 (0.36) | CTSACYP26A1MMP12MMP3MMP9 | |
| SCHEMBL7381395 | 0.82 | CYP26A1 (0.45) | CTSACYP26A1MMP12MMP3MMP9 | |
| SCHEMBL7379465 | 0.81 | CYP26A1 (0.38) | CTSACYP26A1MMP12MMP3MMP9 | |
| SCHEMBL7379462 | 0.81 | CYP26A1 (0.38) | CTSACYP26A1MMP12MMP3MMP9 | |
| Trifluoroacetic Acid SCHEMBL7216313 | 0.76 | MCHR1 (0.35) | CTSACYP26A1MMP12 | |
| Trifluoroacetic Acid SCHEMBL7216213 | 0.76 | ITGB3 (0.34) | CYP26A1MMP12MMP3MMP9MMP8 | |
| SCHEMBL7215549 | 0.76 | DCAF1 (0.31) | MMP12DCAF1 | |
| SCHEMBL7381394 | 0.76 | ITGB3 (0.43) | CTSACYP26A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | disclosed |
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |