Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 1.00 |
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | FLT1 | P17948 | 7/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | ABL2 | P42684 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222290 | 0.84 | EGFR (1.00) | EGFRPDGFRBABL1ABL2BRAF | |
| Hydrochloric Acid SCHEMBL7217999 | 0.82 | EGFR (0.97) | EGFRPDGFRBABL1ABL2BRAF | |
| SCHEMBL1367436 | 0.77 | PDGFRB (0.63) | EGFRKDRPDGFRBABL1ABL2 | |
| SCHEMBL16146468 | 0.71 | BRAF (0.67) | EGFRKDRFLT1PDGFRBBRAF | |
| SCHEMBL1923985 | 0.71 | EGFR (0.63) | EGFRKDRPDGFRB | |
| SCHEMBL7221479 | 0.69 | EGFR (1.00) | EGFRABL1ABL2 | |
| SCHEMBL16009388 | 0.68 | EGFR (0.60) | EGFRKDRPDGFRBABL1ABL2 | |
| SCHEMBL7497652 | 0.68 | EGFR (1.00) | EGFRPDGFRBABL1ABL2BRAF | |
| Hydrochloric Acid SCHEMBL7215766 | 0.68 | EGFR (0.98) | EGFRABL1ABL2 | |
| SCHEMBL2779096 | 0.68 | BRAF (0.52) | EGFRKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |