Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 14/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222295 | 0.80 | EGFR (0.54) | ABCG2ABCB1EGFRABCC1FBP1 | |
| Hydrochloric Acid SCHEMBL7218002 | 0.79 | EGFR (0.53) | ABCG2ABCB1EGFRABCC1FBP1 | |
| SCHEMBL16715186 | 0.70 | QTRT1 (0.51) | FLT1PDGFRBKDR | |
| SCHEMBL5104228 | 0.69 | ABCG2 (1.00) | ABCG2ABCB1ABCC1 | |
| SCHEMBL7215634 | 0.68 | EGFR (1.00) | EGFRFLT1PDGFRBKDR | |
| SCHEMBL7221486 | 0.68 | EGFR (0.54) | ABCG2ABCB1EGFRABCC1FBP1 | |
| SCHEMBL2992623 | 0.67 | EGFR (1.00) | ABCG2EGFRFLT1PDGFRBKDR | |
| Hydrochloric Acid SCHEMBL7215768 | 0.67 | EGFR (0.53) | ABCG2ABCB1EGFRABCC1FBP1 | |
| Hydrochloric Acid SCHEMBL7218038 | 0.67 | GUSB (0.48) | FLT1PDGFRBKDR | |
| Hydrochloric Acid SCHEMBL9017036 | 0.66 | EGFR (0.97) | ABCG2EGFRFLT1PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |