Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazine SCHEMBL7215381 | 0.84 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| Hydrochloric Acid SCHEMBL7221013 | 0.83 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL13738144 | 0.81 | MAPK13 (0.70) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| Hydrochloric Acid SCHEMBL7215094 | 0.80 | MAPK13 (0.70) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| Hydrochloric Acid SCHEMBL7221787 | 0.79 | MAPK13 (0.61) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5914257 | 0.78 | MAPT (0.45) | MAPK14MAPK13MAPK12MAPK11CCNT1 | |
| SCHEMBL7215842 | 0.77 | MAPK13 (0.59) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215845 | 0.77 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215386 | 0.75 | MAPK11 (0.61) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215965 | 0.74 | MAPK13 (0.55) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |