Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 11/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | SDHB | P21912 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001627 | 0.87 | MAPK13 (0.50) | MAPK11MAPK14MAPK13MAPK12MAOB | |
| SCHEMBL7215845 | 0.82 | MAPK14 (0.63) | MAPK11MAPK14MAPK13MAPK12MAOB | |
| SCHEMBL17590 | 0.81 | KMO (0.59) | MAOBKMOSDHBMEN1S1PR4 | |
| SCHEMBL7676169 | 0.80 | KMO (0.47) | MAPK11MAPK14MAPK13MAPK12MAOB | |
| SCHEMBL7215944 | 0.79 | MAPK13 (0.65) | MAPK11MAPK14MAPK13MAPK12MAPK9 | |
| SCHEMBL1384726 | 0.78 | TGFBR1 (0.41) | MAPK11MAPK14MAPK13MAPK12KMO | |
| SCHEMBL7215839 | 0.75 | MAPK14 (0.69) | MAPK11MAPK14MAPK13MAPK12MAPK9 | |
| SCHEMBL14561097 | 0.72 | MAPT (0.44) | MAPK11MAPK14MAPK13MAPK12KMO | |
| SCHEMBL14561100 | 0.72 | BRAF (0.50) | MAPK11MAPK14KMOSDHBMEN1 | |
| SCHEMBL5823023 | 0.72 | CDC7 (0.44) | MAPK14KMOSDHBMEN1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |