Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220914 | 0.88 | MEN1 (0.48) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3238629 | 0.85 | F2 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7214888 | 0.76 | F2 (0.67) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7220542 | 0.74 | F2 (0.47) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7139240 | 0.73 | F2 (0.44) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7159962 | 0.71 | F2 (0.70) | F2PRSS1 | |
| SCHEMBL7809549 | 0.71 | F2 (0.45) | F2PRSS1 | |
| SCHEMBL3238624 | 0.70 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7411110 | 0.69 | F2 (0.47) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7452376 | 0.69 | MEN1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |