Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188271 | 0.78 | F2 (0.50) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7459174 | 0.76 | LMNA (0.48) | F2PRSS1 | |
| SCHEMBL7809549 | 0.76 | F2 (0.45) | F2PRSS1 | |
| SCHEMBL3239431 | 0.74 | F2 (0.67) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7025245 | 0.72 | F2 (0.55) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3238629 | 0.72 | F2 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7452530 | 0.71 | LMNA (0.42) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819546 | 0.71 | F2 (0.41) | F2 | |
| SCHEMBL5474694 | 0.71 | F2 (0.64) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7451716 | 0.70 | LMNA (0.41) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0900207-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997040024-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1997-10-30 | — | — | WO | disclosed |