Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216515 | 0.78 | CNR2 (0.58) | CNR2LRRK2ATRATRIPLMNA | |
| SCHEMBL27684509 | 0.74 | CNR2 (0.43) | CNR2ATRATRIPLMNAHTT | |
| SCHEMBL1869744 | 0.74 | DPP4 (0.58) | POLBDPP4 | |
| SCHEMBL3249571 | 0.74 | CNR2 (1.00) | CNR2RAB9A | |
| SCHEMBL27667321 | 0.69 | CNR2 (0.64) | CNR2LMNAPOLBHTTNPC1 | |
| SCHEMBL6991366 | 0.69 | TACR1 (0.54) | CNR2ATRATRIPCYP1A2CYP3A4 | |
| SCHEMBL17476480 | 0.69 | TACR1 (0.49) | CNR2ATRATRIPLMNACYP1A2 | |
| SCHEMBL21246773 | 0.68 | CNR2 (0.52) | CNR2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4675475 | 0.68 | CNR2 (0.53) | CNR2ATRATRIPLMNAHTT | |
| SCHEMBL27664997 | 0.68 | PIK3CB (0.44) | CNR2LMNAPOLBHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368295-B1 | PROCESS FOR THE MANUFACTURE OF PHENYLACETIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| EP-1368295-A1 | PROCESS FOR THE MANUFACTURE OF PHENYLACETIC ACID DERIVATIVES | F. Hoffman-la Roche AG (CH) | 2003-12-10 | — | — | EP | disclosed |
| US-6531597-B2 | Reacting a halo substituted benzene with a ketone to form a hydroxyalkyl benzene that is carbonylated with a strong acid | HOFFMANN-LA ROCHE INC. | 2003-03-11 | — | — | US | disclosed |
| US-20020156313-A1 | Process for preparation of 2-phenyl acetic acid derivatives | HOFFMANN-LA ROCHE INC. | 2002-10-24 | — | — | US | disclosed |
| WO-2002079134-A1 | PROCESS FOR THE MANUFACTURE OF PHENYLACETIC ACID DERIVATIVES | F. HOFFMANN-LA-ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156313-A1 | Process for preparation of 2-phenyl acetic acid derivatives | ALDH1A1, UGT1A1, PAH | CNR2 3658/4885LRRK2 3987/4885ATR 4486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.