Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7218526 | 0.98 | F2 (0.43) | F2TSHRALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL8236141 | 0.80 | L3MBTL1 (0.50) | F2TSHRALDH1A1L3MBTL1KDM4E | |
| SCHEMBL21468160 | 0.79 | SMN1; SMN2 (0.41) | TSHRALDH1A1KDM4EMMP1MMP2 | |
| SCHEMBL27733842 | 0.79 | SMN1; SMN2 (0.41) | TSHRALDH1A1KDM4EMMP1MMP2 | |
| SCHEMBL1410684 | 0.79 | SMN1; SMN2 (0.41) | TSHRALDH1A1KDM4EMMP1MMP2 | |
| SCHEMBL8991906 | 0.79 | ALDH1A1 (0.42) | F2ALDH1A1KDM4EMMP1MMP2 | |
| SCHEMBL6436784 | 0.78 | TSHR (0.44) | TSHRALDH1A1NPSR1L3MBTL1THRB | |
| SCHEMBL14263864 | 0.78 | TSHR (0.44) | TSHRALDH1A1NPSR1L3MBTL1THRB | |
| SCHEMBL6436779 | 0.78 | TSHR (0.44) | TSHRALDH1A1NPSR1L3MBTL1THRB | |
| SCHEMBL7433429 | 0.77 | ALDH1A1 (0.40) | F2TSHRALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518434-B2 | N-carboxyanhydrides (NCAs) are copupled directly to cyclic amino acids amide derivatives to form peptide linkage | ASTRAZENECA AB (SE) | 2003-02-11 | — | — | US | disclosed |
| EP-1257533-A1 | NEW COUPLING PROCESS | AstraZeneca AB (SE) | 2002-11-20 | — | — | EP | disclosed |
| US-20020128452-A1 | N-carboxyanhydrides (NCAs) are copupled directly to cyclic amino acids amide derivatives to form peptide linkage | ASTRAZENECA AB (SE) | 2002-09-12 | — | — | US | disclosed |
| WO-2001056986-A1 | NEW COUPLING PROCESS | ASTRAZENECA AB (SE) | 2001-08-09 | — | — | WO | disclosed |