Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.62 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.62 |
| ▸ | MMP13 | P45452 | 5/20 | 0.62 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653509 | 1.00 | MMP1 (0.62) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7220886 | 0.92 | MMP1 (0.53) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8435351 | 0.92 | MMP1 (0.66) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8435353 | 0.92 | MMP1 (0.66) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7215046 | 0.87 | MMP1 (0.48) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8576750 | 0.84 | MMP1 (0.56) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL5756389 | 0.84 | MMP1 (0.71) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7105952 | 0.84 | MMP1 (0.71) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL5758290 | 0.82 | MMP1 (0.69) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8432174 | 0.82 | MMP1 (0.61) | MMP1ADAM17MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | claimed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | claimed |
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |