Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653509 | 0.92 | MMP1 (0.62) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7216733 | 0.92 | MMP1 (0.62) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7215046 | 0.86 | MMP1 (0.48) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8435351 | 0.83 | MMP1 (0.66) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8435353 | 0.83 | MMP1 (0.66) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL27573429 | 0.82 | ADAM17 (0.59) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7105952 | 0.76 | MMP1 (0.71) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL5756389 | 0.76 | MMP1 (0.71) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL8576750 | 0.76 | MMP1 (0.56) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL5758290 | 0.75 | MMP1 (0.69) | MMP1ADAM17MMP13MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |