Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220974 | 0.86 | DPP4 (0.38) | LOXL2DPP4DPP8USP2RAB9A | |
| SCHEMBL7214541 | 0.81 | USP2 (0.39) | DPP4DPP8USP2RAB9ALTA4H | |
| SCHEMBL7221460 | 0.78 | KMT2A (0.40) | USP2RAB9ALTA4HROCK2MAPKAPK2 | |
| SCHEMBL7221098 | 0.76 | TAAR1 (0.39) | MAPK14GCGRSLC6A3MAPKAPK2 | |
| SCHEMBL2789136 | 0.76 | LTA4H (0.42) | USP2RAB9ALTA4HCYP19A1MAPK14 | |
| SCHEMBL7221128 | 0.76 | MEN1 (0.36) | DPP4DPP8USP2RAB9ALTA4H | |
| SCHEMBL7216865 | 0.74 | ACHE (0.43) | USP2LTA4HMAPK14SLC6A3 | |
| SCHEMBL4617053 | 0.73 | HRH1 (0.50) | DPP4DPP8CYP19A1SLC6A3 | |
| SCHEMBL7216732 | 0.72 | MAPKAPK2 (0.33) | CYP19A1MAPK14MAPKAPK2 | |
| SCHEMBL7216729 | 0.72 | ACHE (0.48) | LTA4HMAPK14SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |