Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16930335 | 0.85 | SIGMAR1 (0.56) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| SCHEMBL17709282 | 0.82 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL2404037 | 0.81 | LDHA (0.56) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| SCHEMBL10437147 | 0.81 | KDM4E (0.58) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| SCHEMBL10842397 | 0.81 | LDHA (0.56) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| SCHEMBL13623723 | 0.81 | SIGMAR1 (0.47) | ALOX15ALOX12SIGMAR1 | |
| SCHEMBL10776070 | 0.80 | LDHA (0.58) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| SCHEMBL7290411 | 0.80 | LDHA (0.58) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| SCHEMBL7298435 | 0.80 | LDHA (0.58) | LDHAALOX15ALOX12SIGMAR1CA2 | |
| Phyllanthin SCHEMBL503799 | 0.80 | LDHA (0.57) | LDHAALOX15ALOX12CA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339702-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2001068619-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEX INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |