Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 2/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12796882 | 0.87 | MRGPRX4 (0.48) | ENPP3ENPP1NR1H4SMONPC1 | |
| SCHEMBL7217142 | 0.86 | ENPP3 (0.48) | ENPP3ENPP1ALOX15GFERADAM17 | |
| SCHEMBL13287537 | 0.85 | ENPP3 (0.49) | ENPP3ENPP1CHEK1KMT2ANR1H4 | |
| SCHEMBL7215190 | 0.83 | ENPP3 (0.70) | ENPP3ENPP1CHEK1GFERKMT2A | |
| SCHEMBL16378628 | 0.83 | ENPP3 (0.70) | ENPP3ENPP1CHEK1GFERKMT2A | |
| SCHEMBL7215644 | 0.81 | NPC1 (0.58) | ENPP3ENPP1CHEK1KMT2ANR1H4 | |
| SCHEMBL7215456 | 0.81 | NPC1 (0.58) | ENPP3ENPP1CHEK1KMT2ANR1H4 | |
| SCHEMBL12243297 | 0.80 | PLA2G4B (0.52) | ENPP3ENPP1CHEK1NR1H4ALDH1A1 | |
| SCHEMBL16199783 | 0.79 | HSD17B1 (0.57) | ENPP3ENPP1CHEK1KMT2ASMO | |
| SCHEMBL7221671 | 0.78 | NPC1 (0.54) | ENPP3ENPP1ALOX15KMT2ASMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |