Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217150 | 0.86 | ENPP3 (0.48) | ENPP3ENPP1ALDH1A1RAB9ANPC1 | |
| SCHEMBL16378629 | 0.86 | ENPP3 (0.64) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL7220934 | 0.86 | ENPP3 (0.64) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL1000268 | 0.84 | RAB9A (0.51) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL16199782 | 0.82 | CA1 (0.56) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL7221412 | 0.82 | ENPP3 (0.62) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL12243296 | 0.82 | NPC1 (0.50) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL7221944 | 0.81 | ALDH1A1 (0.54) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL7222209 | 0.81 | S1PR1 (0.49) | ENPP3ENPP1MAPTALDH1A1RAB9A | |
| SCHEMBL1853362 | 0.79 | ALOX15 (0.62) | MAPTALDH1A1SMN1; SMN2KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| CN-1314899-A | Retinoid-associated receptor regulators | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-09-26 | — | — | CN | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |