Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12497491 | 0.88 | FAAH (0.43) | ADRB1ADRB3ADRA2AADRA2BADRA2C | |
| SCHEMBL31410591 | 0.87 | MEN1 (0.43) | AAK1APPCES2CES1TDP1 | |
| SCHEMBL15686269 | 0.85 | AAK1 (0.42) | SERPINE1AAK1APPSYKGAA | |
| SCHEMBL29483424 | 0.85 | AAK1 (0.42) | SERPINE1AAK1APPSYKGAA | |
| SCHEMBL16363856 | 0.85 | CTSS (0.45) | ADRB1ADRB3SERPINE1LMNAADRB2 | |
| SCHEMBL2434610 | 0.85 | CTSS (0.45) | ADRB1ADRB3SERPINE1LMNAADRB2 | |
| SCHEMBL19791967 | 0.84 | APP (0.41) | SERPINE1AAK1APPSYKGAA | |
| SCHEMBL10882684 | 0.82 | MAPT (0.56) | ADRB1ADRB3ADRA2AADRA2BADRA2C | |
| SCHEMBL3657534 | 0.82 | GAA (0.48) | LMNAALDH1A1SYKMAPTGAA | |
| SCHEMBL30524647 | 0.81 | F2R (0.43) | ADRB1SERPINE1LMNAHIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |