SCHEMBL7218397

SCHEMBL7218397

CCNC(=O)c1cc(Cl)ccc1Cl

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.67
ALDH1A1 P00352 2/20 0.66
HPGD P15428 2/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
CYP2C19 P33261 1/20 0.64
POLB P06746 1/20 0.57
THRB P10828 1/20 0.57
RECQL P46063 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
TAS1R3 Q7RTX0 1/20 0.55
TAS1R1 Q7RTX1 1/20 0.55
P2RX7 Q99572 1/20 0.55
GPR139 Q6DWJ6 1/20 0.55
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
TP53 P04637 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
KMT2A Q03164 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL27375088 0.98 LMNA (0.65) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL4148502 0.86 POLB (0.76) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL3621390 0.84 P2RX7 (0.56) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL12163930 0.84 LMNA (0.53) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL13753905 0.84 LMNA (0.65) LMNAHPGDPOLBTHRBRECQL
SCHEMBL23430714 0.83 HSD17B10 (0.49) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL7224774 0.83 P2RX7 (0.57) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL11689255 0.83 NOS2 (0.63) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL13381913 0.83 HSD17B10 (0.49) LMNAALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL7219361 0.83 LMNA (0.63) LMNAALDH1A1HPGDCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023192901-A9 QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-14 WO disclosed
WO-2023192901-A1 QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS ESCIENT PHARMACEUTICALS, INC. (US) 2023-10-05 WO disclosed
EP-3370729-B1 METHODS FOR THE IDENTIFICATION, EVALUATION AND TREATMENT OF PATIENTS HAVING MULTIPLE MYELOMA TAKEDA PHARMACEUTICALS CO (JP) 2023-09-27 EP disclosed
EP-3471734-B1 SOLID STATE FORMS OF IXAZOMIB CITRATE TEVA PHARMACEUTICALS INT GMBH (CH) 2020-11-18 EP disclosed
EP-3536693-A1 BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF Millennium Pharmaceuticals, Inc. (US) 2019-09-11 EP disclosed
WO-2017079572-A1 METHODS FOR THE IDENTIFICATION, EVALUATION AND TREATMENT OF PATIENTS HAVING MULTIPLE MYELOMA MILLENNIUM PHARMACEUTICALS, INC. (US) 2017-05-11 WO disclosed
US-7576117-B1 Cyclic amine CCR3 antagonist TEIJIN LIMITED (JP) 2009-08-18 US disclosed
US-7576117-B1 Cyclic amine CCR3 antagonist TEIJIN LIMITED (JP) 2009-08-18 US disclosed
US-6521603-B2 Amide, thioamide, amidine and thioester derivatives containing a benzene, pyridine, thiophene, furan, pyrrole, pyrazole, thiazole or isothiazole ring MONSANTO TECHNOLOGY LLC 2003-02-18 US disclosed
US-6410558-B1 USING INDOLE OR QUINOLINE COMPOUND MONSANTO TECHNOLOGY LLC 2002-06-25 US disclosed
US-RE36562-E CARBOXAMIDE-SUBSTITUTED THIOPHENES MONSANTO COMPANY (US) 2000-02-08 US disclosed
US-5998466-A PREPLANTING MONSANTO COMPANY (US) 1999-12-07 US disclosed
US-5849723-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1998-12-15 US disclosed
US-5834447-A THIOPHENE DERIVATIVES MONSANTO COMPANY (US) 1998-11-10 US disclosed
US-5811411-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1998-09-22 US disclosed
US-5705513-A HETEROCYCLIC FUNGICIDES WITH PYRIDINE OR FURAN RINGS MONSANTO COMPANY (US) 1998-01-06 US disclosed
US-5693667-A Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1997-12-02 US disclosed
US-5498630-A SUBSTITUTED BENZOTHIOPHENECARBOXAMIDES MONSANTO COMPANY (US) 1996-03-12 US disclosed
WO-1993007751-A1 FUNGICIDES FOR THE CONTROL OF TAKE-ALL DISEASE OF PLANTS MONSANTO COMPANY (US) 1993-04-29 WO disclosed
EP-0538231-A1 Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1993-04-21 EP disclosed