Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846334 | 0.88 | HTR1A (0.53) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7215975 | 0.88 | HTR1A (0.60) | HTR1ASLC6A4 | |
| SCHEMBL5844134 | 0.87 | HTR1A (0.61) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL5845602 | 0.78 | HTR1A (0.52) | HTR1ASLC6A4 | |
| SCHEMBL5845943 | 0.78 | ADRA1D (0.44) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL5845948 | 0.78 | ADRA1D (0.44) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7030051 | 0.78 | HTR1A (0.61) | HTR1ASLC6A4 | |
| SCHEMBL7034836 | 0.77 | HTR1A (0.49) | HTR1ASLC6A4 | |
| SCHEMBL7004959 | 0.76 | HTR1A (0.54) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7034985 | 0.76 | HTR1A (0.53) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559169-B2 | For therapy of depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder attention deficit disorder,obsessive compulsive disorder, obesity, eating disorders, sexual dysfunction | WYETH | 2003-05-06 | — | — | US | disclosed |