Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 9/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845471 | 0.87 | HTR1A (0.63) | HTR1ASLC6A4DRD2HTR2ADRD1 | |
| SCHEMBL7030051 | 0.84 | HTR1A (0.61) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL5846334 | 0.82 | HTR1A (0.53) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL7215975 | 0.82 | HTR1A (0.60) | HTR1ASLC6A4DRD2 | |
| SCHEMBL7199693 | 0.78 | MTNR1A (0.50) | — | |
| SCHEMBL7218455 | 0.78 | HTR1A (0.48) | HTR1ASLC6A4 | |
| SCHEMBL7034985 | 0.77 | HTR1A (0.53) | HTR1ASLC6A4DRD2HTR2ADRD3 | |
| SCHEMBL7004959 | 0.77 | HTR1A (0.54) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL7148718 | 0.77 | HTR1A (0.52) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL7032693 | 0.76 | HTR1A (0.51) | HTR1ASLC6A4DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041683-B2 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan | WYETH (US) | 2006-05-09 | — | — | US | disclosed |
| US-6559169-B2 | For therapy of depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder attention deficit disorder,obsessive compulsive disorder, obesity, eating disorders, sexual dysfunction | WYETH | 2003-05-06 | — | — | US | disclosed |