Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11004588 | 0.88 | TSHR (0.59) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| SCHEMBL8616166 | 0.84 | TSHR (0.59) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| SCHEMBL915283 | 0.83 | ALDH1A1 (0.57) | TSHRALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL11004592 | 0.83 | TSHR (0.53) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| SCHEMBL578128 | 0.83 | TSHR (0.77) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| Bromide SCHEMBL2768461 | 0.80 | TSHR (0.57) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| SCHEMBL7669334 | 0.80 | TSHR (0.71) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| SCHEMBL7670783 | 0.80 | TSHR (0.71) | TSHRALDH1A1HSD17B10CDC25BTP53 | |
| Diethyl Phthalate SCHEMBL22296 | 0.78 | TSHR (1.00) | TSHRALDH1A1HSD17B10LMNACDC25B | |
| Diethyl Phthalate SCHEMBL29404255 | 0.78 | TSHR (1.00) | TSHRALDH1A1HSD17B10LMNACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5556996-A | Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity | ALLERGAN (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0626940-A1 | SUBSTITUTED PHENYLETHENYL COMPOUNDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5326898-A | Substituted phenylethenyl compounds having retinoid-like biological activity | ALLERGAN, INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0584191-A1 | NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS. | CIRD GALDERMA (FR) | 1994-03-02 | — | — | EP | disclosed |
| WO-1993016029-A1 | SUBSTITUTED PHENYLETHENYL COMPOUNDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1993-08-19 | — | — | WO | disclosed |
| WO-1992019583-A1 | NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1992-11-12 | — | — | WO | disclosed |