Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253176 | 0.85 | HRH1 (0.60) | HTR1ADRD2ALDH1A1HRH1 | |
| SCHEMBL5729030 | 0.82 | HRH1 (0.62) | HTR1ADRD2HRH1 | |
| SCHEMBL29459507 | 0.78 | HTR1A (0.62) | HTR1ADRD2ALDH1A1DRD3MAOB | |
| SCHEMBL26992312 | 0.78 | HTR1A (0.62) | HTR1ADRD2ALDH1A1DRD3MAOB | |
| SCHEMBL13469510 | 0.78 | HTR1A (0.79) | HTR1ADRD2DRD3MAOB | |
| SCHEMBL7989673 | 0.78 | HTR1A (0.62) | HTR1ADRD2ALDH1A1DRD3MAOB | |
| SCHEMBL5113354 | 0.77 | HTR1A (0.61) | HTR1ADRD2ALDH1A1DRD3MAOB | |
| SCHEMBL10479167 | 0.77 | HRH1 (0.58) | HRH1 | |
| SCHEMBL13590304 | 0.76 | HTR1A (0.53) | HTR1ADRD2ALDH1A1DRD3HTR7 | |
| SCHEMBL5425845 | 0.76 | HTR1A (0.53) | HTR1ADRD2ALDH1A1DRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627630-B1 | Preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria prurigo and antiallergins | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |
| EP-1243271-A1 | NASAL DROPS CONTAINING FUSED PYRIDAZINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-09-25 | — | — | EP | disclosed |
| US-6248740-B1 | FOR SUPPRESSION OF HISTAMINE OR EOSINOPHIL CHEMOTAXIS TO TREAT ASTHMA; ANTIALLERGENIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-06-19 | — | — | US | disclosed |