Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4364349 | 0.98 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL4872642 | 0.89 | ALDH1A1 (0.54) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL5583900 | 0.87 | ALDH1A1 (0.53) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL11480102 | 0.84 | LTA4H (0.50) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL20913146 | 0.83 | RAB9A (0.57) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL11284597 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL11278627 | 0.81 | KCNA3 (0.56) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL15480485 | 0.81 | LTA4H (0.52) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL5583901 | 0.81 | RAB9A (0.55) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A | |
| SCHEMBL11275464 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2LMNAPOLBALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |