Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773731 | 0.73 | PTGS2 (0.51) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL5770740 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL6692601 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL29963704 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL7499779 | 0.69 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL5771902 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL6696054 | 0.68 | PTGS2 (0.45) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL5774427 | 0.67 | POLB (0.47) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL5778314 | 0.67 | MAPT (0.59) | SMN1; SMN2MAPTHTTLMNAABCB1 | |
| SCHEMBL7876671 | 0.66 | SMN1; SMN2 (0.75) | SMN1; SMN2MAPTHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670373-B1 | Inhibiting resistant neoplasms where the resistance is conferred by multidrug resistance protein; N-3,4,5-trimethoxyphenyl-3-(3-azidomethyl-isoxazolo(4,5-c) -1,2-dihydro-6-chloro-quinolin-2-on-1-yl)phenylacetamide | ELI LILLY AND COMPANY | 2003-12-30 | — | — | US | disclosed |