Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774427 | 0.87 | POLB (0.47) | SMN1; SMN2MAPTHTTLMNAIMPDH2 | |
| SCHEMBL5770740 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL5773731 | 0.77 | PTGS2 (0.51) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL6696054 | 0.76 | PTGS2 (0.45) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL5778314 | 0.74 | MAPT (0.59) | SMN1; SMN2MAPTHTTLMNAABCB1 | |
| SCHEMBL5771902 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL7499779 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL7220141 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL5774722 | 0.70 | PTGS2 (0.57) | SMN1; SMN2MAPTHTTLMNAKMT2A | |
| SCHEMBL5776889 | 0.69 | PTGS2 (0.62) | SMN1; SMN2MAPTHTTLMNAABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077675-A1 | Compounds and methods for inhibiting MRP1 | BONJOUKLIAN ROSANNE (US) | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077675-A1 | Compounds and methods for inhibiting MRP1 | ABCC1, ABCB1, ABCB11 | SMN1; SMN2 4456/4885MAPT 4342/4885HTT 3901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.