Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5771902 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AHTTMAPTMEN1 | |
| SCHEMBL5773731 | 0.83 | PTGS2 (0.51) | SMN1; SMN2KMT2AHTTMAPTMEN1 | |
| SCHEMBL7499774 | 0.82 | PTGS2 (0.37) | SMN1; SMN2KMT2AMAPTMEN1LMNA | |
| SCHEMBL5770740 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AHTTMAPTMEN1 | |
| SCHEMBL5778314 | 0.73 | MAPT (0.59) | SMN1; SMN2HTTMAPTLMNAPTGS2 | |
| SCHEMBL6692601 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AHTTMAPTMEN1 | |
| SCHEMBL6696054 | 0.72 | PTGS2 (0.45) | SMN1; SMN2KMT2AHTTMAPTMEN1 | |
| SCHEMBL5776889 | 0.70 | PTGS2 (0.62) | SMN1; SMN2HTTMAPTLMNAPTGS2 | |
| SCHEMBL5773626 | 0.70 | EPAS1 (0.58) | SMN1; SMN2HTTMAPTLMNAPTGS2 | |
| SCHEMBL5774722 | 0.70 | PTGS2 (0.57) | SMN1; SMN2KMT2AHTTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224189-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027116-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |