Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.49 |
| ▸ | TACR3 | P29371 | 4/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220635 | 0.93 | CRHR1 (0.41) | CRHR1CD38 | |
| SCHEMBL7219466 | 0.90 | CRHR1 (0.40) | CRHR1TACR3CD38GABRG2GABRB3 | |
| SCHEMBL7615502 | 0.79 | CRHR1 (0.60) | CRHR1KDM4E | |
| SCHEMBL7609276 | 0.77 | CRHR1 (0.56) | CRHR1KDM4E | |
| SCHEMBL7228514 | 0.77 | CRHR1 (0.61) | CRHR1GABRG2GABRB3GABRA2KDM4E | |
| SCHEMBL7219819 | 0.74 | CRHR1 (0.43) | CRHR1CD38CYP3A4KDM4E | |
| SCHEMBL7226248 | 0.72 | CRHR1 (0.58) | CRHR1CD38GABRG2GABRB3GABRA2 | |
| SCHEMBL7226595 | 0.71 | CRHR1 (0.51) | CRHR1KDM4E | |
| SCHEMBL5599426 | 0.71 | CRHR1 (0.57) | CRHR1CD38 | |
| SCHEMBL5599396 | 0.70 | CRHR1 (0.53) | CRHR1CD38KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525067-B1 | Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime | PFIZER INC | 2003-02-25 | — | — | US | claimed |
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | claimed |
| US-6525067-B1 | Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime | PFIZER INC | 2003-02-25 | — | — | US | disclosed |
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | disclosed |