Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.41 |
| ▸ | CD38 | P28907 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220332 | 0.93 | CRHR1 (0.49) | CRHR1CD38 | |
| SCHEMBL7219466 | 0.89 | CRHR1 (0.40) | CRHR1CD38 | |
| SCHEMBL7228522 | 0.74 | CRHR1 (0.36) | CRHR1CD38 | |
| SCHEMBL7221799 | 0.73 | CRHR1 (0.48) | CRHR1CD38 | |
| SCHEMBL7227694 | 0.72 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL5599563 | 0.72 | NR4A2 (0.50) | CRHR1CD38 | |
| SCHEMBL7615502 | 0.71 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL5599486 | 0.70 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL7609276 | 0.70 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL7228514 | 0.69 | CRHR1 (0.61) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525067-B1 | Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime | PFIZER INC | 2003-02-25 | — | — | US | claimed |
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | claimed |
| US-6525067-B1 | Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime | PFIZER INC | 2003-02-25 | — | — | US | disclosed |
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | disclosed |