Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213780 | 0.78 | HTR1A (0.69) | HTR1ASLC6A4 | |
| SCHEMBL7082302 | 0.77 | HTR1A (0.70) | HTR1ASLC6A4 | |
| SCHEMBL13499597 | 0.76 | SLC6A4 (0.69) | HTR1ASLC6A4 | |
| SCHEMBL28718866 | 0.76 | HTR1A (0.75) | HTR1ASLC6A4 | |
| SCHEMBL29534340 | 0.75 | HTR1A (0.62) | HTR1ASLC6A4 | |
| SCHEMBL28707500 | 0.75 | HTR1A (0.62) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL8171208 | 0.75 | LTA4H (0.55) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL28715827 | 0.75 | HTR1A (0.61) | HTR1ASLC6A4 | |
| SCHEMBL29534330 | 0.75 | HTR1A (0.61) | HTR1ASLC6A4 | |
| SCHEMBL29535418 | 0.74 | HTR1A (0.59) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | claimed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | claimed |
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | disclosed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | disclosed |