Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.40 |
| ▸ | HRH2 | P25021 | 6/20 | 0.40 |
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223288 | 0.84 | MRGPRX4 (0.42) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7228479 | 0.82 | HRH3 (0.56) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7226578 | 0.82 | HRH3 (0.42) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7222806 | 0.81 | KIT (0.46) | HRH3HRH2HRH1ALDH1A1HPGD | |
| SCHEMBL25040866 | 0.81 | MMP2 (0.41) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL23499617 | 0.79 | MMP3 (0.44) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL5624212 | 0.77 | MMP2 (0.60) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL29578385 | 0.76 | TRPV4 (0.43) | — | |
| SCHEMBL10728257 | 0.73 | MRGPRX4 (0.49) | ALDH1A1HPGD | |
| SCHEMBL6709103 | 0.73 | MMP3 (0.59) | HRH3HRH2HRH1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620839-B2 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | ABBOTT LABORATORIES | 2003-09-16 | — | — | US | disclosed |
| US-20020137931-A1 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | ABBVIE INC. | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137931-A1 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | HRH3, HRH4, HRH1 | HRH3 1/4885HRH2 4/4885HRH1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.