Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25280430 | 0.91 | DRD2 (0.45) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL737130 | 0.81 | MEN1 (0.49) | DRD2DRD4DRD3SMN1; SMN2CA12 | |
| SCHEMBL4364349 | 0.81 | SMN1; SMN2 (0.48) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL20572659 | 0.81 | KCNA3 (0.58) | DRD2DRD4DRD3SMN1; SMN2L3MBTL1 | |
| SCHEMBL7220133 | 0.80 | CA12 (0.45) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL7220128 | 0.80 | SMN1; SMN2 (0.47) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL10338308 | 0.77 | MEN1 (0.60) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL28875632 | 0.76 | CYP1A2 (0.49) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL10935809 | 0.76 | DRD2 (0.52) | DRD2DRD4DRD3CA12CA1 | |
| SCHEMBL167606 | 0.76 | DRD2 (0.56) | DRD2DRD4DRD3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| CN-1247531-A | Arylsulfonyl hydroxamic acid derivatives | PFIZER (US) | 2000-03-15 | — | — | CN | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |