Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7221509 | 0.99 | HIF1A (0.54) | HIF1AEPAS1HSP90AA1HSP90AB1HSD17B10 | |
| Hydrochloric Acid SCHEMBL7221783 | 0.85 | HIF1A (0.56) | HIF1AEPAS1HSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL7221113 | 0.80 | NPC1 (0.69) | HIF1AEPAS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL487161 | 0.73 | HIF1A (0.55) | HIF1AEPAS1HSP90AA1HSP90AB1 | |
| SCHEMBL487458 | 0.73 | HSP90AA1 (0.56) | HIF1AEPAS1HSP90AA1HSP90AB1 | |
| SCHEMBL7221925 | 0.71 | NPC1 (0.62) | HIF1AEPAS1HSD17B10NPC1RAB9A | |
| SCHEMBL7222661 | 0.71 | POLH (0.62) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL7227797 | 0.69 | POLH (0.56) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL28762700 | 0.68 | CCNC (0.80) | HIF1AHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7221843 | 0.68 | NPC1 (0.63) | HIF1AEPAS1HSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552054-B1 | For prophylaxis and therapy of bone diseases and chondropathy | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-1211251-A1 | CHROMONE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |