Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 11/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216072 | 0.93 | HTR1A (1.00) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL7213986 | 0.90 | HTR1A (1.00) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL7549298 | 0.82 | HTR1A (1.00) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL6594841 | 0.81 | HTR1A (0.68) | HTR1ASLC6A4DRD2DRD4HTR2A | |
| SCHEMBL7214578 | 0.78 | HTR1A (1.00) | HTR1ASLC6A4DRD2HTR7 | |
| SCHEMBL5843574 | 0.76 | HTR1A (0.75) | HTR1ASLC6A4DRD2 | |
| SCHEMBL15064476 | 0.75 | SLC6A4 (0.69) | HTR1ASLC6A4DRD2DRD4HTR2A | |
| SCHEMBL791945 | 0.74 | DRD2 (0.70) | HTR1ASLC6A4DRD2DRD4HTR2A | |
| SCHEMBL790948 | 0.73 | DRD2 (0.72) | HTR1ASLC6A4DRD2DRD4HTR2A | |
| SCHEMBL7463051 | 0.72 | HTR1A (0.64) | HTR1ASLC6A4DRD2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | claimed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | claimed |
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | disclosed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | disclosed |