Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 9/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220964 | 0.93 | HTR1A (1.00) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL7213986 | 0.90 | HTR1A (1.00) | HTR1ASLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL7549298 | 0.82 | HTR1A (1.00) | HTR1ASLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6594841 | 0.76 | HTR1A (0.68) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL5845217 | 0.76 | HTR1A (0.66) | HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL6976036 | 0.75 | HTR1A (0.63) | HTR1ASLC6A4DRD2ADRA1DHTR1D | |
| SCHEMBL7881295 | 0.73 | HTR1A (0.81) | HTR1ASLC6A4DRD2ADRA1DHTR1D | |
| SCHEMBL7214578 | 0.72 | HTR1A (1.00) | HTR1ASLC6A4DRD2MAPK1 | |
| SCHEMBL5478675 | 0.72 | HTR1A (1.00) | HTR1A | |
| SCHEMBL6591284 | 0.71 | DRD2 (0.59) | HTR1ASLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | claimed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | claimed |
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | disclosed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | disclosed |