Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222432 | 1.00 | GAA (0.48) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL7228369 | 0.97 | ALDH1A1 (0.46) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL7229389 | 0.86 | KDM4E (0.47) | GAAALDH1A1SMN1; SMN2HRH3MGLL | |
| SCHEMBL7222004 | 0.86 | SIGMAR1 (0.43) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL7234008 | 0.83 | KDM4E (0.48) | GAAALDH1A1SMN1; SMN2STAT6HRH3 | |
| SCHEMBL7694509 | 0.83 | CHRM5 (0.44) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL9562409 | 0.81 | ALDH1A1 (0.39) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL7230380 | 0.81 | SIGMAR1 (0.37) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL7287324 | 0.80 | GAA (0.46) | GAAALDH1A1SMN1; SMN2STAT6MEN1 | |
| SCHEMBL10528030 | 0.80 | GAA (0.46) | GAAALDH1A1SMN1; SMN2STAT6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552226-B1 | Rapid; low temperature; one pot synthesis; reduced catalytic quantities of such as lewis acid and tertiary amine; entiomerically pure products | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-04-22 | — | — | US | disclosed |
| WO-2002026683-A1 | TANDEM ACYL-CLAISEN REARRANGEMENT IN THE PREPARATION OF CHIRAL PRODUCTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-04 | — | — | WO | disclosed |