Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505401 | 0.88 | SMN1; SMN2 (0.53) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7217216 | 0.87 | RAB9A (0.71) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7217156 | 0.85 | KDM4E (0.72) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7215145 | 0.85 | MAPT (0.61) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5698744 | 0.84 | KDM4E (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL7215820 | 0.84 | KDM4E (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7215217 | 0.84 | KDM4E (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7217201 | 0.82 | KDM4E (0.56) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27560241 | 0.82 | LOXL2 (0.61) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7220948 | 0.81 | NPC1 (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| CN-1314899-A | Retinoid-associated receptor regulators | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-09-26 | — | — | CN | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |