Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 9/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215876 | 0.87 | GAA (0.47) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7222129 | 0.86 | HSP90AA1 (0.48) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7221568 | 0.85 | GRIA1 (0.53) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7221055 | 0.84 | GRIA1 (0.54) | PTGS1PTGS2GRIA1GAAMAPK1 | |
| SCHEMBL7216642 | 0.82 | GRIA1 (0.46) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7216663 | 0.77 | CA1 (0.46) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7222428 | 0.77 | GAA (0.55) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7221208 | 0.74 | PTGS2 (0.59) | PTGS1PTGS2GRIA1GAAMAPK1 | |
| SCHEMBL7217043 | 0.73 | CA1 (0.55) | PTGS1PTGS2CA9CA12CA1 | |
| SCHEMBL7218478 | 0.73 | PTGS2 (0.60) | PTGS1PTGS2GRIA1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | claimed |
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | disclosed |