Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222297 | 0.86 | PTGS1 (0.44) | PTGS2PTGS1SCDCA12CA1 | |
| SCHEMBL7217043 | 0.86 | CA1 (0.55) | HSP90AA1HSP90AB1PTGS2PTGS1CDK4 | |
| SCHEMBL7222836 | 0.85 | ALDH1A1 (0.54) | PTGS2PTGS1AKT1AKT2ALDH1A1 | |
| SCHEMBL7217176 | 0.85 | PTGS2 (0.50) | HSP90AA1HSP90AB1PTGS2PTGS1CDK4 | |
| SCHEMBL7218261 | 0.84 | AKT1 (0.57) | HSP90AA1HSP90AB1PTGS2PTGS1CDK4 | |
| SCHEMBL7218068 | 0.81 | PLAU (0.46) | PTGS2PTGS1CDK4CDK2AKT1 | |
| SCHEMBL7221387 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1CDK2ALDH1A1 | |
| SCHEMBL7218447 | 0.78 | USP7 (0.60) | PTGS2PTGS1CDK2AKT1AKT2 | |
| SCHEMBL7222063 | 0.77 | CA2 (0.49) | PTGS2PTGS1CDK4CDK2AKT1 | |
| SCHEMBL7222378 | 0.74 | PTGS2 (0.50) | PTGS2PTGS1CDK4CDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | claimed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | claimed |
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | disclosed |
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | disclosed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | disclosed |