Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.48 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.48 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | MATK | P42679 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | FRK | P42685 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221208 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1GRIA1MAPK1KDM4E | |
| SCHEMBL7221055 | 0.88 | GRIA1 (0.54) | PTGS2PTGS1GRIA1CSNK1A1CSNK1D | |
| SCHEMBL12781591 | 0.87 | GRIA1 (0.62) | GRIA1CSNK1A1CSNK1DPRKD3MAPK9 | |
| SCHEMBL7216301 | 0.86 | GAA (0.56) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL3522362 | 0.83 | GRIA1 (0.58) | GRIA1CSNK1A1CSNK1DPRKD3MAPK9 | |
| SCHEMBL7217081 | 0.83 | PTGS2 (0.62) | PTGS2PTGS1ALDH1A1KDM4EHPGD | |
| SCHEMBL8565114 | 0.83 | PTGS2 (0.62) | PTGS2PTGS1ALDH1A1KDM4EHPGD | |
| SCHEMBL7215562 | 0.83 | PTGS2 (0.50) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL3524010 | 0.81 | PRKD3 (0.59) | GRIA1CSNK1A1CSNK1DPRKD3MAPK9 | |
| SCHEMBL7217007 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | claimed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | claimed |
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | disclosed |
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | disclosed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | disclosed |